Resources

Software, reusable graphics, and presentation materials developed in or around the lab.
BindCraft2
MIT license

The next generation of our user-friendly platform for de novo protein binder design. BindCraft2 is dramatically faster and more memory-efficient, and adds new modalities such as antibody-format (VHH/scFv), multi-target, and conformation-specific binders, while keeping the hands-off filtering that makes designs ready to order with high experimental success rates.

Binder design
Antibodies
Linux
CUDA
Open source
BindCraft2
Matthews Probability Calculator
Colab

A python implementation of the Matthews probability calculator that estimates the solvent content and number of protein copies in the crystal asymmetric unit.

X-tal
Protein
Web browser
Matthews Probability Calculator
Start-up settings for ChimeraX
Settings

Commands that can be pasted into start-up settings in ChimeraX (Preferences->Startup) to improve default visualisation and provide button shortcuts for styling.

ChimeraX
Visualisation
Start-up settings for ChimeraX
Protein Sequence Biophysical Analysis
Colab

A simple python notebook to calculate the biophysical properties of protein sequences, such as molecular weight, charge, isoelectric point, extinction coefficient, absorbance, amino acid composition, etc.

Protein
Analysis
Web browser
Protein Sequence Biophysical Analysis
Oligonucleotide Property Calculator
Colab

An online interface to calculate the properties of oligonucleotides, in terms of molecular weight, melting temperature, absorbance, GC factor, and concentration based on 260 nm absorption.

Nucleic acid
Web browser
Oligonucleotide Property Calculator